Prof. Andrew Griffiths
École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), FR
Laboratoire de Biochimie
Professor of Biochemistry
Supervisor DC3 and DC7
Full Professor of Biochemistry at ESPCI. Molecular biologist specialising in high-throughput screening, selection and directed evolution. Supervised 31 PhD students, currently supervising 4. Founder of 5 start-ups. Member of the Executive Committee at ESPCI Paris, and the steering committee of the program “Origins and conditions for the appearance of life” at PSL. Authored and co-authored >120 publications.
Selected publications
- Fallah-Araghi, A., Meguellati, K., Baret, J. C., El Harrak, A., Mangeat, T., Karplus, M., … & Griffiths, A. D. (2014). Enhanced chemical synthesis at soft interfaces: A universal reaction-adsorption mechanism in microcompartments. Physical Review Letters, 112(2), 028301. https://doi.org/10.1103/PhysRevLett.112.028301
- Ryckelynck, M., Baudrey, S., Rick, C., Marin, A., Coldren, F., Westhof, E., & Griffiths, A. D. (2015). Using droplet-based microfluidics to improve the catalytic properties of RNA under multiple-turnover conditions. Rna, 21(3), 458-469. https://doi.org/10.1261/rna.048033.114
- Matsumura, S., Kun, Á., Ryckelynck, M., Coldren, F., Szilágyi, A., Jossinet, F., … & Griffiths, A. D. (2016). Transient compartmentalization of RNA replicators prevents extinction due to parasites. Science, 354(6317), 1293-1296. https://doi.org/10.1126/science.aag158
- Obexer, R., Godina, A., Garrabou, X., Mittl, P. R., Baker, D., Griffiths, A. D., & Hilvert, D. (2017). Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase. Nature chemistry, 9(1), 50-56. https://doi.org/10.1038/nchem.2596
- Eyer, K., Doineau, R. C., Castrillon, C. E., Briseño-Roa, L., Menrath, V., Mottet, G., … & Baudry, J. (2017). Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring. Nature biotechnology, 35(10), 977-982. https://doi.org/10.1038/nbt.3964
